![]() and B.C.) and European Research Council grant 716058 (K.M.C. and B.C.) Swiss National Center of Competence in Chemical Biology (K.M.C. and B.C.) Swiss National Center of Competence for Molecular Systems Engineering (K.M.C. and J.-H.C.) Swiss National Science Foundation (K.M.C. and D.T.) Amgen (S.L.) the Human Frontier Science Program Cross Disciplinary Fellowship (LT000395/2020-C) and EMBO Non-Stipendiary Fellowship (ALTF 1047-2019) (L.F.M.) the EMBO Fellowship (ALTF 191-2021) (T.S.) European Molecular Biology Organization Grant (ALTF 139-2018) (B.I.M.W.) the “la Caixa” Foundation (M.E.) the National Institute of Allergy and Infectious Diseases (NIAID) Federal Contract HHSN272201700059C (I.A.), NIH grant DP5OD026389 (S.O.) the National Science Foundation MCB 2032259 (S.O.) the Howard Hughes Medical Institute (D.B., R.R., and K.M.C.), the National Institute on Aging grant 5U19AG065156 (D.B., J.L.W., D.R.H., and M.E.) the National Cancer Institute grant R01CA240339 (D.B. and W.Y.) the DARPA Harnessing Enzymatic Activity for Lifesaving Remedies project HR001120S0052 contract HR-0012 (N.B.) the Washington Research Foundation (J.W.) the Open Philanthropy Project Improving Protein Design Fund (D.B. and J.D.) Eric and Wendy Schmidt by recommendation of the Schmidt Futures (D.J.) the DARPA Synergistic Discovery and Design project HR001117S0003 contract FA8750-17-C-0219 (D.B. This work was supported with funds provided by the Audacious Project at the Institute for Protein Design (D.B. Wicky, Andrew Muenks, Frank DiMaio, Bruno Correia, Sergey Ovchinnikov, and David Baker +21 authors +19 authors +14 authors fewer Authors Info & Affiliationsįunding: We thank Microsoft for support and for providing Azure computing resources. Hicks, Marc Expòsit, Thomas Schlichthaerle, Jung-Ho Chun, Justas Dauparas, Nathaniel Bennett, Basile I. Milles, , Minkyung Baek, Ivan Anishchenko, Wei Yang, Derrick R. The procedure yielded scaffold-related variants with nanomolar affinity. We demonstrated its functionality by training it as a binder against human interleukin-10, a medically important cytokine. Castro, Robert Ragotte, Amijai Saragovi, Lukas F. The newly developed scaffold, called ProBi (Protein Binder), contains two independently mutable surface patches. Jue Wang, Sidney Lisanza, , David Juergens, Doug Tischer, , Joseph L.
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